Fig. 6

Sex difference in gut microbiome structure (a), and phylogenetic diversity (b). Red dots represents female mice microbiomes and blue dots represent those analyzed from male mice. The PCoA plot is based on weighted UniFrac distances between all OTUs identified in female and male mice. Female mice showed a significant difference from male mice by ANOSIM with 999 permutations analysis (p < 0.05). In b, microbiomes harbored in female mice exhibited a significantly lower PD value than male mice. * p < 0.05