Fig. 1: Effect of seven Citrus flavonoids on URAT1-mediated urate transport. | npj Science of Food

Fig. 1: Effect of seven Citrus flavonoids on URAT1-mediated urate transport.

From: Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

Fig. 1

a, b Expression and plasma membrane localization of URAT1 in 293A cells. A fluorescent wheat germ agglutinin conjugate (WGA) was used to visualize plasma membranes. Bars, 5 μm. c URAT1 inhibition by benzbromarone (10 μM). ††P < 0.01 (two-sided t-test); NS not significant. d Inhibitory effect of each flavonoid (15 μM) on URAT1-mediated urate transport. Data are expressed as the mean ± SD. n = 4. *P < 0.05; **P < 0.01 vs control (Dunnett’s test).

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