Fig. 5: ANX A1 is required for the hepato-protective effects of sesamin and SC1 in the CCl4-induced liver damage model.
From: Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites
a, b Effect of sesamin administration on the CCl4-induced liver damage in WT or ANX A1-KO mice. WT or ANX A1-KO mice (C57BL/6J) were intraperitoneally administered CCl4, and sesamin (25 mg kg−1 body weight), or vehicle was orally administered twice at 1 h before and 7 h after CCl4 administration. Hepatic damage marker enzymes (AST, ALT or LDH) in the plasma were measured 24 h after CCl4 administration (a). Data represent the mean ± SE. n = 13–15 mice in each group. *p < 0.05 using unpaired Student’s t test. The liver section was histologically evaluated using H&E staining (b). P and C indicated the portal and central vein, respectively. Scale bar: 50 μm. c, d Effect of SC1 on the CCl4-induced liver damage in WT or ANX A1-KO mice. SC1 (50 mg kg−1 body weight) or vehicle was intraperitoneally administered twice at 1 h before and 7 h after CCl4 administration. AST, ALT and LDH in the plasma, 24 h after CCl4 administration, were measured (c). Data represent the mean ± SE. n = 9–14 mice in each group. **p < 0.01 using unpaired Student’s t test. (d) The liver section was histologically evaluated using H&E staining. Scale bar: 50 μm.
