Fig. 7: Schematic representation of the anti-inflammatory effect of SC1 mediated by ANX A1 activation. | npj Science of Food

Fig. 7: Schematic representation of the anti-inflammatory effect of SC1 mediated by ANX A1 activation.

From: Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Fig. 7

SC1 is produced by metabolising sesamin in hepatocytes. In monocytes, SC1 directly binds to the repeat 3 domain of Ca2+ form ANX A1. Under stimulated conditions like PMA/LPS in monocytes, SC1 promotes the phosphorylation of ANX A1 Ser27 and the subsequent extracellular release of ANX A1, and thereby eliciting an anti-inflammatory effect via the suppression of TNFα or MCP-1 production.

Back to article page