Fig. 1: RA improve cognitive function in 3 × Tg-AD mice.

a The structure of rosmarinic acid (RA). b–d Spatial memory is improved by feeding with an RA-supplemented diet. b Y-maze test scheme. c The number of arm entries are similar in both groups. d The spatial memory is lower in the control (Cont) group. e–f Memory for objects is improved in mice fed an RA-supplemented diet. e Acquisition and test scheme for novel object recognition test (NORT). f NORT suggests RA improved cognitive function for object recognition. Data are shown as means ± standard error. Cont, n = 8; RA, n = 9, *p < 0.05, **p < 0.01.