Table 2 KEGG pathways enriched in the rosmarinic acid group.

From: Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway

KEGG pathway

Annotated genes

Fold enrichment

p-value

mmu04022: cGMP-PKG signaling pathway

19

3.7

<0.0001

mmu04723: Retrograde endocannabinoid signaling

13

4.2

<0.0001

mmu05210: Colorectal cancer

9

4.7

0.00056

mmu04915: Estrogen signaling pathway

11

3.8

0.00062

mmu04724: Glutamatergic synapse

11

3.2

0.00212

mmu01212: Fatty acid metabolism

7

4.6

0.00376

mmu04727: GABAergic synapse

9

3.5

0.00413

mmu05213: Endometrial cancer

7

4.5

0.00415

mmu04270: Vascular smooth muscle contraction

11

2.9

0.00437

mmu04114: Oocyte meiosis

10

3.1

0.00525

mmu05032: Morphine addiction

9

3.2

0.00619

mmu05033: Nicotine addiction

6

5.0

0.00620

mmu04728: Dopaminergic synapse

11

2.8

0.00637

mmu04978: Mineral absorption

6

4.9

0.00690

mmu04730: Long-term depression

7

3.9

0.00908

mmu04110: Cell cycle

10

2.7

0.01124

mmu04350: TGF-beta signaling pathway

8

3.2

0.01281

mmu04720: Long-term potentiation

7

3.6

0.01316

mmu05215: Prostate cancer

8

3.1

0.01530

mmu04668: TNF signaling pathway

9

2.8

0.01545

mmu04918: Thyroid hormone synthesis

7

3.4

0.01723

mmu04924: Renin secretion

7

3.3

0.01837

mmu04971: Gastric acid secretion

7

3.3

0.01956

  1. Enrichment analysis of 549 differentially expressed genes, with a false discovery rate of 0.05, has identified enrichment for 23 KEGG pathways. Significance criteria were a p value of < 0.02 with the modified Fisher’s exact test and a fold enrichment score of >2.7. The terms are listed according to their p values.