Table 2 EC50 values derived from the in vitro data on the neurotoxicity of MGO in human neuronal cell models reported in the literature
Human neuronal cell models | EC50a, (μM) | Exposure time, (h) | Endpoints | References |
|---|---|---|---|---|
SH-SY5Y | 710.0 | 24 | Mitochondrial function (MTT assay) | |
SK-N-MC | 372.9 | 48 | Mitochondrial function (WST assay) | |
SK-N-SH | 1179.0 | 24 | Mitochondrial function (Resazurin assay) | |
M17 | 809.2 | Unspecified | Viability assessment (method unspecified) | |
Human induced pluripotent stem cell (iPSC)-derived neurons | >1000 | Unspecified | Viability assessment (method unspecified) | |
hNLCs | 340.5 | 24 | Mitochondrial function (MTT assay) | |
hNLCs | 298.3 | 48 | Mitochondrial function (MTT assay) | |
hNLCs | 312.1 | 24 | Cytotoxicity (trypan blue exclusion test) | |
hNLCs | 220.8 | 48 | Cytotoxicity (trypan blue exclusion test) | |
hNLCs | Not Determinedb | 24 | Apoptosis (nuclear staining with Hoechst 33258 dye) | |
hNLCs | Not Determinedb | 48 | Apoptosis (nuclear staining with Hoechst 33258 dye) |
