Fig. 7: Potential mechanisms for the ameliorative effect of ALSL. | npj Science of Food

Fig. 7: Potential mechanisms for the ameliorative effect of ALSL.

From: Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice

Fig. 7

ALSL was innovatively synthesized from lauric acid and linseed oil using an acidolysis enzymes method and fed (1500 mg/kg) to high-fat diet (HFD) C57BL/6 mice. ALSL significantly ameliorated HFD-induced obesity, glucose-lipid homeostasis, systemic inflammation, and IR, and it also significantly upregulated the abundance of Lactobacillus, Bifidobacterium, Dubosiella, and downregulated Ileibacterium. In addition, ALSL upregulated acetic acid and propionic acid levels and activated hepatic receptors for short-chain fatty acids (GPR43, GPR41), thus exerting an ameliorative regulatory effect.

Back to article page