Table 3 Association of daily consumption of green tea and coffee with total brain volume, total hippocampal volume and white matter lesion volume in older adults without dementia

From: Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Daily consumption (ml)

No. of Participants

Model 1

Model 2

TBV/eTIV (%)

HV/eTIV (%)

WMLV/eTIV (%)

TBV/eTIV (%)

HV/eTIV (%)

WMLV/eTIV (%)

Green tea

0 ~ 200

2498

59.00 (58.87–59.12)

0.4951 (0.4927–0.4974)

0.3978 (0.3826–0.4130)

58.38 (58.15–58.61)

0.4915 (0.4870–0.4961)

0.4939 (0.4652–0.5226)

201 ~ 400

1114

59.07 (58.90–59.25)

0.4980 (0.4947–0.5014)

0.3967 (0.3751–0.4182)

58.39 (58.12–58.65)

0.4934 (0.4882–0.4986)

0.5039 (0.4711–0.5367)

401 ~ 600

1536

59.09 (58.95–59.24)

0.4967 (0.4938–0.4995)

0.3762 (0.3579–0.3944)

58.43 (58.18–58.68)

0.4925 (0.4876–0.4974)

0.4830 (0.4522–0.5138)

601~

3054

59.09 (58.98–59.21)

0.4998 (0.4976–0.5021)

0.3641 (0.3495–0.3786)

58.41 (58.18–58.64)

0.4949 (0.4904–0.4995)

0.4781 (0.4494–0.5067)

p for trend

0.654

0.032*

< 0.001*

0.959

0.240

0.007*

Coffee

0 ~ 200

4921

59.05 (58.96–59.14)

0.4967 (0.4949–0.4984)

0.3832 (0.3720–0.3944)

58.39 (58.17–58.61)

0.4922 (0.4878–0.4965)

0.4914 (0.4643–0.5186)

201 ~ 400

1908

59.05 (58.92–59.19)

0.4986 (0.4960–0.5012)

0.3706 (0.3540–0.3872)

58.35 (58.10–58.59)

0.4940 (0.4892–0.4988)

0.4818 (0.4517–0.5119)

401 ~ 600

1083

59.19 (59.02–59.37)

0.4992 (0.4958–0.5026)

0.3957 (0.3740–0.4175)

58.58 (58.32–58.84)

0.4957 (0.4905–0.5008)

0.4945 (0.4623–0.5267)

601~

290

58.76 (58.43–59.08)

0.4963 (0.4900–0.5027)

0.3735 (0.3326–0.4144)

58.16 (57.77–58.54)

0.4917 (0.4841–0.4992)

0.4571 (0.4098–0.5043)

p for trend

0.126

0.407

0.170

0.072

0.262

0.171

  1. eTIV estimated total intracranial volume, HV hippocampal volume, IQR interquartile range, TBV total brain volume, WMLV white matter lesions volume.
  2. Values were shown as a mean (95% confidence interval).
  3. Model 1 was adjusted for age, sex, research site, and educational levels.
  4. Model 2 was further adjusted for the presence of Apolipoprotein E ε4 allele, hypertension, diabetes mellitus, history of stroke, electrocardiogram abnormalities, smoking habit, alcohol intake, regular exercise, body mass index levels, serum low-density lipoprotein and high-density lipoprotein cholesterol levels, regular exercise, and smoking and drinking habits.
  5. ∗ p for trend < 0.05.