Fig. 8: Diet containing a low amount of Phgg also promoted colon tumorigenesis.

a Experiment timeline. b Probability of survival. c Percent change in body weight. d Representative gross colon images. e Tumor-occupied area as a percentage of total colon area. f Representative images of H&E-stained colon sections (original magnification, ×16, ×100). g Representative images displaying immunohistochemical staining for β-catenin (red, upper panel) and Ki67 (green). DAPI was used to visualize the nucleus [blue, (original magnification, ×200)]. Quantitative evaluation of (h) β-catenin (nuclear localization) and i Ki67 positive cells normalized per unit area. Values are presented as mean ± SEM. *p < 0.05, ***p < 0.001.