Fig. 5: MB regulates hepatic gene expression profiles in mice. | npj Science of Food

Fig. 5: MB regulates hepatic gene expression profiles in mice.

From: Monobutyrin can alleviate hepatic lipid dysmetabolism and improve liver mitochondrial ultrastructure and autophagy in high-fat diet mice

Fig. 5

A PCA score plots; B Volcano plot of DGEs. Each dot represents a particular gene, and its corresponding horizontal and vertical values are gene expression changes in the NC and HFD groups or HFD and HFD + 2MB groups, respectively. The red dots mean up-regulated genes expressed significantly, and the blue dots mean down-regulated genes expressed significantly. C GO enrichment analysis. The vertical axis represents GO terms and the horizontal axis is the Rich factor. D KEGG pathway analysis. E Heatmap cluster analysis of DGEs in the fatty acid biosynthesis pathways; F Heatmap cluster analysis of DGEs in the lipid transport pathways; G Heatmap cluster analysis of DGEs in the PPAR signaling pathways related to fatty acid oxidation. n = 6 mice per group.

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