Fig. 6: Impact of C@MSN-P-A8 on bone loss in osteoporotic rats.
From: Bone-targeted celastrol nanocarrier suppresses osteoclastogenesis in postmenopausal osteoporosis
A Micro-CT image and statistical analysis of three-dimensional reconstruction for bone parameters, including BMD, BV/TV, Tb. Th, Tb. Sp, and Tb. N in each group of rats. The left image represents the best-case sample, and the right image represents the worst-case sample within each group, along with statistical analysis of bone parameters (Scale bar = 1 mm). B Representative H&E-stained images of rat femurs with green arrows indicating trabeculae and black arrows indicating bone marrow cavities (Scale bar=1 mm/200 μm). The left image represents the best-case sample, and the right image represents the worst-case sample within each group, along with statistical analysis of bone parameters. C Representative TRAP-stained images of rat femurs and quantitative analysis of osteoclast numbers on each bone surface (Scale bar = 100/25 μm). Yellow arrows represent osteoclasts. ‘ns’ indicates no significant difference between the two groups, * represents comparison between the two groups, **P < 0.01, ***P < 0.001. Each group consisted of six mice.
