Fig. 5: Luteolin ameliorates NRF2 stability.

A Genes expression of Nrf2 and Keap1 in primary hepatocytes (n = 6–8). B Protein expression of NRF2 and KEAP1 in primary hepatocytes (n = 4, 5). C NRF2 protein degradation in primary hepatocytes (n = 3, 4). D KEAP1 protein degradation in primary hepatocytes (n = 3, 4). Values represent the means ± SD. #p < 0.05 vs. Con group; *p < 0.05 vs. Eth group. Con control group, Eth ethanol group.