Fig. 7: Schematic diagram of the potential mechanisms by which luteolin prevents alcoholic liver injury. | npj Science of Food

Fig. 7: Schematic diagram of the potential mechanisms by which luteolin prevents alcoholic liver injury.

From: Luteolin protects against alcoholic liver injury by restoring NRF2 stability to suppress ACSS2 nuclear accumulation

Fig. 7: Schematic diagram of the potential mechanisms by which luteolin prevents alcoholic liver injury.

Alcoholic metabolism progression that ethanol dehydrogenase catalyzes ethanol converting to acetaldehyde, is usually along with reactive oxygen species (ROS) production. ROS promotes the nuclear accumulation of ACSS2, driving the acetyl-CoA production. Acetyl-CoA enhanced the histone H3 acetylation and the expression of hepatic lipogenic genes including Srebp-1c, Fasn and Acaca. Luteolin restored NRF2 stability to suppress the ROS reaction, contributing to the prevention of alcoholic liver disease. Acaca acetyl-CoA carboxylase alpha, ACSS2 acetyl-CoA synthetase short-chain family member 2, Fasn fatty acid synthase, NRF2 nuclear factor erythroid 2-related factor 2, ROS reactive oxygen species, Srebp-1c sterol regulatory element binding transcription factor 1c.

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