Fig. 3: Effects of LEP fractions on renal function, inflammation and oxidative stress in HUA rats.

The levels of UA (A), BUN (B), and CRE (C) in serum. Renal fibrotic area (D). Micrographs of HE (E) and masson (F) staining kidney (200 ×). The relative mRNA expression levels of IL-1β (G), TNF-α (H), IL-6 (I) and IL-10 (J) in kidney. IHC staining representative images of CD68 at 200 × (upper row) and 800 × (bottom row) (K). The levels of CAT (L), GSH (M), and SOD (N) in the kidney. #p <0.05, ##p <0.01 and ###p <0.001 vs. NC group; *p <0.05, **p <0.01 and ***p <0.001 vs. MC group. ++p <0.01 and +++p <0.001 vs. sample groups.