Table 4 Parameterization of the torsemide mean value model
Molecule | Parameter | Value | Unit |
|---|---|---|---|
Torsemide | Fraction unbound | 1.25E-01 | % |
Torsemide | Lipophilicity | 2.023 | [–] |
Torsemide | Molecular weight | 348.8 | g/mol |
Torsemide | Intestinal permeability | 1.66E-05 | cm/min |
Torsemide | CYP2C9 kcat | 20 | 1/min |
Torsemide | CYP2C9 Km | 1 | µmol/l |
Torsemide | OATP1B1 kcat | 30 | 1/min |
Torsemide | OATP1B1 Km | 1 | µmol/l |
Torsemide | Renal clearance | 0.0013 | l/min/kg |
OH-torsemide | Fraction unbound | 1.91E-01 | % |
OH-torsemide | Lipophilicity | 2.139 | [–] |
OH-torsemide | Molecular weight | 364.42 | g/mol |
OH-torsemide | CYP2C9 kcat | 70 | 1/min |
OH-torsemide | CYP2C9 Km | 1 | µmol/l |
OH-torsemide | OATP1B1 kcat | 50 | 1/min |
OH-torsemide | OATP1B Km | 1 | µmol/l |
OH-torsemide | Renal clearance | 0.007 | l/min/kg |
