Fig. 5
From: A multiscale model of early cell lineage specification including cell division
a Results of different in silico treatments. Red lines denote the periods of the Erk-pathway inhibition (va = 0, Eq. (3) in Fig. 1), whereas the blue lines denote the periods of addition of exogenous Fgf4 (vex = 0.2, Eq. (5) in Fig. 1). For each in silico experiment (A to P), we show the reference to the corresponding experiment, and the simulation outcome. Line K* corresponds to a partial inhibition of the Erk-pathway, i.e., va = 10. b Embryo evolution in the experiment J for the period from E3.75 to E4.5. The top row shows the embryo snapshots during the evolution, whereas the bottom row shows the levels of Nanog and Gata6 at the corresponding times
