Fig. 4
TDL predictions and lipidomics measurements. a Fold changes of statistically different genes between GF and M8 mice ileums which are implicated in affecting lipid metabolism in the ileum. Genes are sorted based on their implications in different aspects of TDL. First column indicates whether a corresponding gene is implicated in impacting lipid metabolism via GEMs (G – if yes, else -), via LMPD (L – if yes, else -) and via Reactome (R – if yes, else -). Second column indicates the corrected p values after FDR correction. Third column indicates the gene name. Green filled bars indicate higher expression in GF, while red filled bars indicate higher expression levels in M8 mice ileum. b Logarithm of the ratios of the average levels of statistically different lipids between GF and M8 mice ileums are shown. Green filled bars indicate higher lipid levels in GF, while red filled bars indicate higher levels in M8 mice ileum. Blue filled bars indicate lipids observed only in GF samples and yellow filled bars indicate lipids observed only in M8 mice samples. Lipids are sorted based on type. Gray circles with numbers across panel a and panel b illustrate which gene tabulated in panel a is predictive of which lipid species or lipid classes shown in panel b. For example, gene ACAA1 marked with gray circle with the number 1 is predictive of alterations in the levels of the lipid LTB4. GEMs genome-scale metabolic models, LMPD LIPID MAPS, remaining lipids are tabulated in Table 2
