Fig. 2 | npj Systems Biology and Applications

Fig. 2

From: Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

Fig. 2

Scheme of the ADME processes implemented in the PBPK models. Thirty-two biological processes representing ADME behavior in the developed PBPK models of a diclofenac, b celecoxib, c zileuton, d licofelone, and e rifampicin (red; parent drugs) illustrating active drug transport (influx, efflux; green), metabolizing reactions for phase I and phase II metabolites (blue), as well as specific clearance processes (renal, hepatic, and biliary; gray, yellow, and light green). Metabolic enzymes and transporters are presented next to the respective reaction. Diclofenac, DFN; hydroxy, OH; acyl glucuronide, AGLU; celecoxib, CEL; carboxy, COOH; glucuronide, GLU; zileuton, ZLT; sulfoxide, SO; licofelone, LCF; rifampicin, RIF; desacetyl, DA

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