Fig. 5 | npj Systems Biology and Applications

Fig. 5

From: Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

Fig. 5

Correlation of PGE2 decrease with pain relief. Predicted decrease in PGE2 formation over time compared with the drug-free treatment is correlated with mean pain relief scores observed in patients after 6 h for a 25 mg, 50 mg, and 100 mg diclofenac, and b 400 mg celecoxib. Placebo effects of both studies are additionally shown. Celecoxib, CEL; diclofenac, DFN; prostaglandin E2, PGE2

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