Fig. 4: IgAN-contextualized network from CARNIVAL. | npj Systems Biology and Applications

Fig. 4: IgAN-contextualized network from CARNIVAL.

From: From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL

Fig. 4

The network summarizes the CARNIVAL results for node penalty β = 0.8. This network consists of 43 TFs, 37 input nodes and 62 associated nodes which are connected through 231 edges. Up-regulated nodes and activatory reactions are indicated in blue while down-regulated nodes and inhibitory edges are colored in red. Triangles correspond to transcription factors, diamonds represent input nodes and circlescor respond to purely inferred nodes. Members of the most dysregulated gene set, i.e. adherens junctions, are labeled by more intense background colors

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