Fig. 4: Interrelation between cholesterol, sphingomyelin and phosphatidylcholine proportions in the membrane of M. pneumoniae as simulated by iEG158_mpn when grown in silico on the predicted optimal serum-free medium.
From: Model-driven design allows growth of Mycoplasma pneumoniae on serum-free media
a If cholesterol constitutes 35% of the total membrane lipids, phosphatidylcholine (PC) proportion is up to 10%, while sphingomyelin/sphingolipids is reduced at its minimum to 12%. b If cholesterol constitutes 50% of the membrane lipids, phosphatidylcholine (PC) proportion decreases to 6%, while sphingomyelin increases to 15%. Outer cycle represents the average proportions of acyl chains carried by each lipid, as also showed in Fig. 3: the gray colors represent, in order of shading from the lightest to the darkest, C16:0, C16:1, C18:0, C18:1, C18:2.
