Fig. 2: Pathway map of measured changes in lipid mediators between control and polyI:C treatment: SBML format via CellDesigner; GML format via VANTED: effect of polyI:C treatment on lipid mediators in plasma.

a Fold changes in lipid mediators induced by polyI:C versus control treatment, mapped in SBML format using CellDesigner. Metabolites not included and not detected are shown as small grey circles and larger grey circles, respectively. Metabolites showing a log2 fold change (polyI:C/saline) > 0.3 or < -0.3 (P < 0.05) are drawn with a thick outline; related enzymes/receptors are highlighted. Lines with an arrow show a metabolic reaction; lines with an open circle, connected to a metabolic reaction, show an enzymatic reaction. The receptor, ion channel, and enzymes associated with the pathway of changed lipid mediator profile is indicated by light green and light yellow symbols, respectively. The receptor, ion channel, and enzyme associated with the pathway of significantly changed lipid mediator between polyI:C and saline are drawn with a thick outline. b Mean (± s.e.m) amounts of lipid mediator measured in plasma after saline (blue column) and polyI:C (red column) treatment were mapped in GML format using VANTED. Metabolites not included and not detected in the analysis are shown as small black circles and grey squares, respectively. Lines with arrows show a metabolic reaction. Colors indicate the metabolite grouping for lipid derived mediators: red; AA, purple; LA, salmon pink; GLA and EDA, blue; DGLA, pink; Lyso-PAF and PAF, orange; AEA, yellow; ALA, light green; EPA, and light blue; DHA. **P < 0.01, *P < 0.05.