Fig. 1: Deterministic and hybrid stochastic simulations of the model.
From: A hybrid stochastic model of the budding yeast cell cycle
a, b The temporal dynamics of representative proteins (a) and mRNAs (b) generated by the deterministic model. The volume of the cell increases exponentially and is divided (at the arrows) asymmetrically between mother (\(55 \%\)) and daughter cell (\(45 \%\)). c, d Stochastic simulation of the same proteins (c) and mRNAs (d) as in panels a and b, generated by a representative run of our hybrid stochastic model. Similar to the deterministic model, the cell grows exponentially; however, at the time of division all species in the cell, except for Cln3 and Bck2, are partitioned between daughter and mother cells with a 40:60 ratio, according to observations by Di Talia et al.28. Cln3 and Bck2, which are preferentially retained in mother cells56,57, are partitioned with a ratio 20:80 between daughter and mother cells. The daughter cell is tracked from division to division in this simulation.
