Table 2 Parameter values for the coarse-grained resource allocation model.
From: Optimal proteome allocation and the temperature dependence of microbial growth laws
Parameter | Symbol | Reference value (source) | Calibrated value | Units |
|---|---|---|---|---|
Maximum synthesis rate for precursors | ||||
in glucose-minimum medium | \({k}_{M}^{ref}\) | 3.6 (a) | 1.54 ± 0.12 | /h |
in rich medium | \({\tilde{k}}_{M}^{ref}\) | 3.6 (a) | 9.99 ± 1.61 | /h |
Maximum synthesis rate for proteins | \({k}_{R}^{ref}\) | 3.6 (a) | 8.42 ± 1.13 | /h |
Protein folding/unfolding rate ratio | \({k}_{f}^{ref}/{k}_{u}^{ref}\) | 200 (b) | 357 ± 60 | h/h |
Activation energy for the synthesis rates | EM, ER | 45,000 (c) | 41,900 ± 5,200 | J/mol |
Activation energy for protein folding | Ef | 84,000 (d) | 489,000 ± 81,000 | J/mol |
Pseudo activation energy for protein unfolding | Eu | 36,400 (e) | 575,000 ± 97,000 | J/mol |
Deformation parameter for protein unfolding | d | −0.033 (e) | −0.094 ± 0.025 | – |
Half-saturation constant for protein synthesis | Kp | 0.003 (a) | – | g/g |
House-keeping protein mass fraction | q | 0.46 (f) | – | g/g |
Inactive ribosomal protein mass fraction | r0 | 0.138 (f) | – | g/g |
