Fig. 1: Description of modeling approaches. | npj Systems Biology and Applications

Fig. 1: Description of modeling approaches.

From: MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks

Fig. 1

A MethylCapsNet: separate MLPs are utilized to form capsule level embeddings from beta values of CpG groupings, which are then associated with outcome targets of interest through dynamic routing of information; these embeddings may be studied to propose networks based on comethylation on the individual level. B MethylSPWNet aggregates the beta values of groups of CpGs through one locally connected layer; nodes of the resulting layer represent biologically meaningful units that are passed through an MLP for final prediction; group L1 penalties are applied to prune genes/capsules potentially unrelated to the outcome; red colors indicate beta values for CpGs, which serve as input to the algorithm.

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