Fig. 6: Description of framework. | npj Systems Biology and Applications

Fig. 6: Description of framework.

From: MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks

Fig. 6

a User selects capsules to group sets of CpGs from their own supplied list or a prespecified annotation set. b User selects the modeling approach, MethylCapsNet, MethylSPWNet, Group LASSO. c Hyperparameter search conducted to reveal ideal model specification. d Final models are fit, and capsules are interrogated for relationships with one another, relationships to the outcome, and highly weighted CpGs; yellow indicates an important capsule; MethylCapsNet relates the capsule to each other per individual; MethylSPWNet locates important CpGs within a capsule and contextualizes its location; input data into the algorithm are colored red.

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