Fig. 4: Chromatin remodeling observed for many post-induction repressed ERGs in subcluster 2. | npj Systems Biology and Applications

Fig. 4: Chromatin remodeling observed for many post-induction repressed ERGs in subcluster 2.

From: IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells

Fig. 4

a Heatmaps of time-course fold change in expression from data of all post-induction repressed genes that were demonstrated by the 3-state cycle model or model v4 (highlighted in orange). Genes shown in the heatmaps all belong to the ERGs in subcluster 2. b Heatmaps of time-course chromatin accessibility at κB sites in promoter regions of ERGs, IRGs, and DRGs in subcluster 2, which showed the start of decrease in chromatin accessibility at least at 30 (light brown box) or 75 (brown box) min in both Ctrl and siIκBα. Genes highlighted with orange are post-induction repressed ERGs in subcluster 2 that were best demonstrated by 3-state cycle model or model v4. Genes highlighted with purple are genes that were demonstrated by any of the 4 models but did not show post-induction repression in data.

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