Fig. 5: NAD(P)+ and tetrahydrofolate (THF) synthesis in BB-12 and BB-46. | npj Systems Biology and Applications

Fig. 5: NAD(P)+ and tetrahydrofolate (THF) synthesis in BB-12 and BB-46.

From: Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale modeling

Fig. 5: NAD(P)+ and tetrahydrofolate (THF) synthesis in BB-12 and BB-46.

a Proposed pathways of NAD(P)+ biosynthesis in BB-12 and BB-46: In contrast to BB-46, BB-12 lacks a gene coding for nicotinamidase (EC 3.5.1.19), which catalyzes the conversion of nicotinamide into nicotinic acid (NNAM), as well as genes required for biosynthesis of nicotinate D-ribonucleotide (nicrnt) from L-aspartate (asp-L) and fumarate (fum). b Proposed pathways of folate biosynthesis in BB-12 and BB-46: Both strains cannot synthesize para-aminobenzoic acid. BB-12 further lacks a gene coding for dihydropteroate synthase (EC 2.5.1.15), catalyzing the condensation of para-aminobenzoic acid and 6-hydroxymethyl-dihydropterin pyrophosphate (6hmhptpp) (DHPS2). Abbreviations of metabolite and reaction names are the same as used in the models (Supplementary Data 3 and 4).

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