Fig. 1: An overview of the direct and indirect effects of AgNPs mediated oxidative stress on gut bacterial metabolism in treatment and management of CRC.
From: Metabolic modeling of host–microbe interactions for therapeutics in colorectal cancer
AgNPs are known to mediate their direct cytotoxic effects through increased generation of reactive species inside the target cells. Besides, the AgNP-generated oxidative stress can also affect the cellular metabolism and certain pathways of interest (in this case, the anti-cancer metabolites) thereby enhancing indirect cytotoxicity. Gut microbe-CRC interactions can further assist in understanding the role of gut bacterial metabolites (indirect effects of ROS) on CRC metabolism.
