Fig. 1: General scheme of our single-GC eMS model. | npj Systems Biology and Applications

Fig. 1: General scheme of our single-GC eMS model.

From: Understanding repertoire sequencing data through a multiscale computational model of the germinal center

Fig. 1

Founder B cells enter the GC and go through a process of division and SHM in the DZ and selection in the LZ, based on the affinity of their BcRs. Each B cell (CB/CC) represented by the ABM embeds a GRN that is affected by BcR and CD40 signaling to drive PC differentiation. The affinity of BcRs can assume values between 0 and 1 and is based on an abstract shape space.

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