Fig. 5: Results from nine simulations showing the evolution of the average clonal sizes of all clones (purple) and all the dominant clones (green) during a 21-day GC reaction. | npj Systems Biology and Applications

Fig. 5: Results from nine simulations showing the evolution of the average clonal sizes of all clones (purple) and all the dominant clones (green) during a 21-day GC reaction.

From: Understanding repertoire sequencing data through a multiscale computational model of the germinal center

Fig. 5

The y axis is gapped between 2500 and 4000 cells to facilitate the visualization. Dominant clones were defined as those with abundances higher or equal than the 75th percentile of clonal abundances. The shaded area represents the minimum and maximum of the mean values for each group obtained from the simulations. When the number of clones within a group is low, changes on its clonal composition (a clone may stop belonging to the group because it stops fitting the criteria or because it is outcompeted and removed) lead to big changes in the means.

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