Fig. 6: Lineage trees of all founder cells from one representative simulation.

Lineage trees of all founder cells from one representative simulation (Simulation 1; Table 1) ordered by the appearance of the founder cell in the GC (x axis) and with their daughter cells shown at their time of the appearance in the GC (y axis). Approximately 200 lineages each derived from founder cells that enter between t = 0 and t = 115 h evolve through the GC reaction. See Supplementary Fig. 8 for an individual B-cell lineage. The x axis shows the timepoints at which the founder cells enter the GC. The y axis shows the evolution of the clones during 21 days (504 h). Colors denote affinity of each individual cell. Apoptotic B cells due to lethal mutations in a FWR (non-functional BcR) appear in black. The initial affinity of the founder cells is 0.01 (yellow). Each lineage comprises a mixture of GC B cells, MBCs, and PCs. Eighteen clones survived in the GC at day 21, while the other clones have been outcompeted and disappeared from the GC reaction.