Fig. 7: Clonal affinity at day 21. | npj Systems Biology and Applications

Fig. 7: Clonal affinity at day 21.

From: Understanding repertoire sequencing data through a multiscale computational model of the germinal center

Fig. 7

Boxplots representing clonal affinity, showing the large variation in subclonal affinity for 18 surviving clones in the GC at day 21 of a representative simulation (Simulation 1; Supplementary Table 2). The boxplots are sorted and labeled according to the cell count of their corresponding clone. A strong correlation between clonal abundance and affinity that we expected to result from clonal expansion in combination with affinity maturation, is absent. In addition, we also observe highly abundant but low-affinity clones and vice versa. Horizontal line: median. Boxes: 25th and 75th percentiles. Whiskers: 1.5 times the interquartile range. Dots: outliers. The top 5 clones are dominant according to the threshold of ≥=75th percentile of clonal abundances (blue) while the top 13 clones are dominant according to the threshold of ≥=0.5% of the cell counts (red).

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