Fig. 3: Model agreement with the insulin signaling data.
From: A comprehensive mechanistic model of adipocyte signaling with layers of confidence
Data comes from isolated human adipocytes stimulated with insulin in different doses and for different times18. In all panels, lines represent the model simulation with the best agreement to data, the shaded areas represent the model uncertainty, and experimental data points are represented as mean values with error bars (SEM). Simulations and experimental data in red correspond to experiments under type 2 diabetic conditions, and in blue under non-diabetic conditions. The model agreement was assessed with a χ2-test, as described in the “Statistical analysis” section.
