Fig. 6: Predicting the effect of isoprenaline on glucose uptake.
From: A comprehensive mechanistic model of adipocyte signaling with layers of confidence
The model predicts that 10 nM isoprenaline (iso) increases the glucose uptake both without insulin and with low doses of insulin. However, above 10 nM insulin, glucose uptake is maximal and cannot further be augmented by isoprenaline. Lines correspond to the simulated glucose uptake as the response to insulin stimulation, where the uptake is expressed as the percentage of the maximal uptake. Solid lines correspond to the glucose uptake in the absence of isoprenaline, and dashed lines correspond to glucose uptake in the presence of 10 nM isoprenaline. Both insulin and isoprenaline were added at time point 0, and the response was measured after 30 min. Blue and red lines correspond to normal or type 2 diabetic (T2D) conditions respectively.
