Fig. 5: Model validation. | npj Systems Biology and Applications

Fig. 5: Model validation.

From: A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective

Fig. 5

Comparison of node activities between the quiescent single state attractor and the two severe eight states attractors (Supplementary Figures 4–7) is depicted. a Nodes are grouped by their pathway association. The colored rectangles show the nodes’ activities changes in the severe attractors with proliferative, angiogenic, and detachment properties compared to the quiescent one. Green rectangles represent nodes that are completely upregulated from quiescent to aggressive attractors. Gray rectangles represent nodes that are down regulated from quiescent to aggressive attractors. Rectangles with both activities represent oscillatory behaviors. Here, the arrows indicated if the overall resulting activity is up (up pointing arrow) or down (down pointing arrow) in the compared attractor patterns. Blue rectangles indicate unchanged activities. A detailed analysis of this validation can be found in Supplementary Table 3. b Distribution of alterations in the activity levels between the quiescent and the two severe WT attractors is shown. c Among the 56 nodes of the network, we were able to validate the activity of 39 nodes (69.6%).

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