Fig. 1: A schematic diagram of the apoptotic signaling network. | npj Systems Biology and Applications

Fig. 1: A schematic diagram of the apoptotic signaling network.

From: Computational modeling of DLBCL predicts response to BH3-mimetics

Fig. 1: A schematic diagram of the apoptotic signaling network.

Lines correspond to interactions between different species, with open circles, closed dots, and perpendicular lines denoting activation, binding, and inhibition/sequestration. Dashed lines correspond to the translocation of species. Some translocations are omitted as most BH3-only proteins and anti-apoptotic BCL2s are continuously trafficking between the cytoplasm and the MOM. Complete model details are provided in the supplemental modeling methodology and full code defining and running the model is available on GitHub (https://github.com/SiFTW/BH3Models). “Apoptotic signaling” represents any upstream activators of apoptosis, such as Fas/TRAIL activity. BCL2A1 is displayed as “A1”.

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