Fig. 3: Cell line-specific computational models recapitulate experimentally measured protein expression and heterodimerisation profiles and enable accurate prediction of the optimal BH3-mimetic for each cell line. | npj Systems Biology and Applications

Fig. 3: Cell line-specific computational models recapitulate experimentally measured protein expression and heterodimerisation profiles and enable accurate prediction of the optimal BH3-mimetic for each cell line.

From: Computational modeling of DLBCL predicts response to BH3-mimetics

Fig. 3: Cell line-specific computational models recapitulate experimentally measured protein expression and heterodimerisation profiles and enable accurate prediction of the optimal BH3-mimetic for each cell line.

A Right: Comparison of the relative protein expression in the computational model to experimental data. Abundance of each protein is normalized to the most highly expressed anti-apoptotic BCL2 family protein and quantified from ref. 13. Left: Comparison of the proportion of pro-apoptotic and BH3-only BCL2 proteins bound to the dependent anti-apoptotic BCL2 protein in each line in the computational simulation compared to experimental data. B Model simulations (left) of cell population viability (%) in response to 10 different strengths of BH3-mimetics compared to experimentally-measured EC50 values.

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