Fig. 5: Oscillatory behaviour of TP53 and the mitochondrial proteins. | npj Systems Biology and Applications

Fig. 5: Oscillatory behaviour of TP53 and the mitochondrial proteins.

From: A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint

Fig. 5

a Trap spaces show that along with TP53 and MDM2, mitochondrial proteins like BAX and cytoplasmic protein CASP9 remain unfixed. b Simulation with CC shows TP53 and MDM2 oscillations while all inputs remain active. c Simulation with CC shows oscillatory behaviour of the mitochondrial proteins when all inputs remain active.

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