Fig. 4: Evolution of T cell states and associated differentiation models.
From: A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion
a–h Single T cell (SC) tracking intermediary states defined by PP (pink) or EE (green) gene activation (SC1-SC8). Each SC simulation heatmap displays the evolution of gene activation (colored; ON) or inactivation (white; OFF). Frequency distribution bars above the heatmap show the fraction of PP or EE genes at each time step. Diagrams for each SC simulation represent a simplified visualization of the evolution of each intermediate T cell state from naïve state (TN) to terminally differentiated state pro-memory (TT, pink) or exhausted (TT, green).
