Fig. 8: Boolean model of CD8+ T cell exhaustion.
From: A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion
a Literature-based network diagram of key gene regulatory interactions underlying TCE. Black arrows indicate activation; red lines with bars on the end indicate inhibition. Stimulating and inhibitory immune receptors are shown in yellow with black dashed borders. Pink nodes represent proliferative pro-memory-associated genes; green nodes represent effector exhausted-associated genes. b Schematic outline of T cell state progression from naïve to terminal differentiation.
