Fig. 3: Impact of dose fractionation strategies on treatment outcome. | npj Systems Biology and Applications

Fig. 3: Impact of dose fractionation strategies on treatment outcome.

From: Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion

Fig. 3

Here the total dose is fixed (arbitrarily at 50), and the effect of fractionating this cumulative dose by number of doses and spacing between them is evaluated. a Binary outcome of whether the tumor is eliminated (green) or not (red). b Area under the curve (\({AU}{C}_{0-\tau }\), where \(\tau\) represents spacing between doses), (c) Minimum concentration at steady state (\({C}_{\min }\)) and (d) average concentration at steady state (\({C}_{{\rm{avg}}}\)), corresponding to each dose number-dose spacing combination.

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