Fig. 4: In silico simulation of ERK1 and Notch1 KOs in the RA M1 macrophage model.
From: Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis
a Simulation with ERK1 inactive and Notch1 active in the model. The Proliferation phenotype gets inhibited in the absence of ERK1. b Simulation with ERK1 and Notch1 inactive in the model. The Apoptosis phenotype gets activated and the Proliferation phenotype gets inhibited in the absence of ERK1 and Notch1.
