Fig. 11: Model structure.
From: Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model
PSMA ligands in interstitial space associate/disassociate reversibly to free PSMA receptors with the rate of koff and kon. Ligand receptors and free PSMAs are endocytosed with the rate constant of kint and ke,c, respectively. During internalization, a fraction of PSMA is recycled back to the plasma membrane at a constant rate (krec). The remaining receptors (f1, f2) are degraded in the maturing endosome and eventually in the lysosome (kdeg). Total PSMA receptor biosynthesis combines constitutive Vr and ligand-induced synthesis ksyn.
