Fig. 2: In the Inter-DC network, each brain region uses a distinct gene profile to interact with other brain regions.

a Schematic Inter-DC network between Frontal Pole (FP) and other three brain regions, depicting distinctive dysregulation patterns. b Stacked bar graph denotes that each brain region has an exclusive set of genes mostly when interacting with other brain regions in the DC network. c Hub gene NTM from STG is differentially correlated with 35 genes in FP. The edge color represents the category of Inter-DC relation. Green (solid line) represents positively gained, and red (dashed line) represents negatively gained. d In this network, NTM from PHG is differentially correlated (positively gained in DC) to only one gene ALMS1 in IFG. e The Spearman correlation coefficients between the hub gene NTM and its Inter-DC partner genes (noted in panel c, d) are shown for the CTL and AD conditions as boxplots, both for FP-STG and PHG-IFG inter-brain-region comparisons. Boxplots in this figure and elsewhere in this paper show the median as the center line, upper and lower quartiles as box limits, 1.5x interquartile range as whiskers, and outliers outside the whiskers as points.