Fig. 5: A bioinformatics ecosystem for data analysis, integration and modelling in IDT implementations.
From: Immune digital twins for complex human pathologies: applications, limitations, and challenges
Stepwise process to obtain a DT implementation that accommodates different types of input data, integrative methods, and modelling formalisms to template model building, simulation, and analysis to create personalised instantiations for therapeutic interventions. The predictions can be tested using in vitro assays using humanised cellular systems (like organoids) and in silico population trials.
