Table 2 A summary of AI description of model codes

From: Leveraging public AI tools to explore systems biology resources in mathematical modeling

AI tool

Model recognition features

M1

M2

M3

Meta AI

Recognized species names, e.g. that Dp might represent a phosphorylated form of the molecule D, DpG appears to be a compound that represents the complex formed by the interaction of Dp (a phosphorylated form of protein/molecule D) and Grb2.

P

P

P

Phind

Described interactions as conversions, e.g. describing aggregation of Dp and Grb2 as a “conversion of Dp into DpG, facilitated by Grb2”.

P

P

P

Perplexity

Correctly described small models, stating that Ra is a Receptor–ligand complex and dimerization of two activated receptor complexes forms a Dimerized receptor complex. However, for larger models Perplexity generated different answers and was never able to accurately describe what the model was depicting.

F

W

W

  1. The columns M1, M2, M3 correspond to comprehension of Models 1–3 by AI, with F meaning Full, P—partial, and W—wrong. Other tools from Table 1 not listed here describe data structure only, providing no biological interpretation.
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