Fig. 2: Data and fits for the two-population model.
From: Understanding therapeutic tolerance through a mathematical model of drug-induced resistance
a Mean across four replicates of the normalized cell count data from33 and model fits. Best model fits are shown at a drug concentration of (b) 0.032 μM, (c) 0.32 μM, and (d) 3.2 μM. The estimate of the standard error of the sample mean (SEM) across four replicates, are shown in blue in (b–d). The relative value of the cost function is ζnorm = 11.43 for the dose of 0.032 μM, ζnorm = 14.42 for the dose of 0.32 μM, and ζnorm = 21.56 for the dose of 3.2 μM. The fitting process results in time course predictions for the respective sizes of the sensitive (S shown in the dashed green curve) and resistant (R shown in the dotted black curve) cell subpopulations.
