Table 3 Summary of AD biodomain knowledge graphs
Biological domain | Nodes (mRNA) | Edges (mRNA) | Nodes (Proteins) | Edges (Proteins) |
|---|---|---|---|---|
APP Metabolism | 147 | 316 | 87 | 154 |
Apoptosis | 958 | 10,963 | 451 | 3261 |
Autophagy | 505 | 2665 | 304 | 1096 |
Cell Cycle | 728 | 6561 | 337 | 1779 |
Endolysosome | 1096 | 8909 | 665 | 3874 |
Immune Response | 1507 | 16,354 | 688 | 4683 |
Lipid Metabolism | 1671 | 13,515 | 891 | 4366 |
Metal Binding and Homeostasis | 801 | 4822 | 441 | 1398 |
Mitochondrial Metabolism | 1273 | 7092 | 858 | 3493 |
Myelination | 189 | 348 | 120 | 132 |
Oxidative Stress | 346 | 2080 | 185 | 637 |
Proteostasis | 2675 | 29,812 | 1477 | 13,323 |
Structural Stabilization | 2245 | 23,850 | 1297 | 12,163 |
Synapse | 2067 | 21,056 | 1234 | 9686 |
Tau Homeostasis | 45 | 90 | 41 | 81 |
Vasculature | 756 | 7098 | 356 | 2008 |
